RAMP1 polyclonal antibody
产品名称： RAMP1 polyclonal antibody
英文名称： RAMP1 polyclonal antibody
产品编号： PAB14648
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of RAMP1.
- Immunogen:
- A synthetic peptide corresponding to amino acids 98-113 of human RAMP1.
- Sequence:
- GRYFRSCPISGRAVRD
- Host:
- Rabbit
- Reactivity:
- Chimpanzee, Human, Macaque
- Specificity:
- The amino acid sequence used is 100% homologous in human and chimp, and 87% homologous in rhesus monkey.
- Form:
- Liquid
- Storage Buffer:
- In serum (50% glycerol, 0.025% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:100-1:1000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Novel function for receptor activity-modifying proteins (RAMPs) in post-endocytic receptor trafficking.
Bomberger JM, Parameswaran N, Hall CS, Aiyar N, Spielman WS.J Biol Chem. 2005 Mar 11;280(10):9297-307. Epub 2004 Dec 21.
- 2.
- The extracellular domain of receptor activity-modifying protein 1 is sufficient for calcitonin receptor-like receptor function.
Fitzsimmons TJ, Zhao X, Wank SA.J Biol Chem. 2003 Apr 18;278(16):14313-20. Epub 2003 Feb 6.
- Application Image
- ELISA
- Entrez GeneID:
- 10267
- Protein Accession#:
- NP_057532
- Gene Name:
- RAMP1
- Gene Alias:
- -
- Gene Description:
- receptor (G protein-coupled) activity modifying protein 1
- Omim ID:
- 605153
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. [provided by RefSeq
- Other Designations:
- calcitonin receptor-like receptor activity modifying protein 1,receptor (calcitonin) activity modifying protein 1,receptor activity modifying protein 1,receptor activity-modifying protein 1
- Gene Pathway
- Related Disease